Question

Based on the abstract below what is the goal of this paper and what is their hypothesis?

While the epidermal growth factor receptor (EGFR) is an established regu osine kinase receptors ERBB2 and ERBB3 in this tissue have only recently been examined. Previously reported, skin-specific deletion of each of these receptors in mice resulted in similar defects in keratinocyte proliferation Because both ERBB2 and ERBB3 are targets for treating an array of can cer types, it is important to examine the consequences of receptor inhibi- 5 0 ERBB3 showed comparable reductions in cell proliferation as assessed by BrdU staining. Apoptosis, in contrast, was reduced in ERBB3-deficient (scratch) assay showed that the closure of the wound gaps was completed human keratinocytes. These observations might bear significance to patient

Answer 1

The goal of the paper = To establish the consequences of inhibition of epidermal growth factor receptor-related tyrosine kinase receptors ERBB2 and ERBB3 in human keratinocytes.

Hypothesis - tyrosine kinase receptors ERBB2 and ERBB3 plays a major role in normal proliferation and migration of human keratinocytes.