Below are data from a micropipette aspiration test to determine whether a mutation in spectrin af...
Below are data from a micropipette aspiration test to determine whether a mutation in spectrin affects red blood cell (RBC) area modulus Ma. The RBC is swollen using a series of four hypotonic solutions (i.e. HS1, HS2, HS3, HS4). As the solutions become more hypotonic and the RBC swells, more vacuum must be applied to hold the cell in the micropipette. For each HS, cell radius is measured. Assume Rp - 0.4 um. Estimate Ma from these data. How does this value compare to Ma for normal RBCs, as indicated in the notes? (Units: dynes/cm) HS4 16.09 x 10 HS3 HS2 HS1 3.56 x 10 4.50 4.72 Cell Radius (um)
Below are data from a micropipette aspiration test to determine whether a mutation in spectrin affects red blood cell (RBC) area modulus Ma. The RBC is swollen using a series of four hypotonic solutions (i.e. HS1, HS2, HS3, HS4). As the solutions become more hypotonic and the RBC swells, more vacuum must be applied to hold the cell in the micropipette. For each HS, cell radius is measured. Assume Rp - 0.4 um. Estimate Ma from these data. How does this value compare to Ma for normal RBCs, as indicated in the notes? (Units: dynes/cm) HS4 16.09 x 10 HS3 HS2 HS1 3.56 x 10 4.50 4.72 Cell Radius (um)