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Suggest any application of HMMs to a biological problem OTHER TAHn the applications 5' splice sti...

Suggest any application of HMMs to a biological problem OTHER TAHn the applications 5' splice stie recognition, CpG islands, protein trans-membrane segment prediction, or protein secondary structure prediction. Suggest a reasonable HMM topology that could be applied to the problem.

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An application of HMM to a biological problem is SNPs identification in the sequencing data(next generation). In research, identification of SNPs are important as often they are associated with a particular disease or phenotype.


A probabilistic Hidden Markov Model could be applied for the detection of SNPs.Here,g-degree relatives pedigree is used where two input individuals are present with a single ancestor but their paths are separate.

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