Question

S RROwn as nucleophilic addition. The C-O bond is highly polarized, making carbonyl compounds electrophilic at carbon. If the Grignard reagent reacts with an aldehyde, ketone or ester, the ultimate product is an alcohol. Overall Reaction 0 Br Me PartA Part B Pre-lab questions (15 points) Show the mechanism of the reaction of bromobenzene with magnesium metal in anhydrous diethyl ether There are many inert solvents that could be used but diethyl ether was chosen because it can assist the preparation of a Grignard reagent. How so? 1. 2. Grignard reagent 56 3. The reaction to form a Grignard (and use it) requires "anhydrous" conditions. List one thing that is done before this lab that ensures "anhydrous" conditions: 4. Why do we use anhydrous diethyl ether in Part A of this reaction? Why does the procedure call for dry glassware? Think about what would happen if water was present. Write equation. 5. How many equivalents of Grignard reagent are used in this reaction compared to the limiting reagent? 6. What is the fate of the methoxy group from the methyl benzoate in this reaction? 7. Draw the setup of a simple distillation apparatus. Include the names of all glassware. 8. What is the molecular weight and melting point of triphenylmethanol? hemicals Week 1: Mg turnings (1.2 g), anhydrous diethyl ether (-40 mL), bromobenzene (4.7 mL), 1,2- ibromocthane (L drop), methyl-benzoate (2.5 mL), 6M sutfuric acid (25 mL eek 2: MTBE (-20 mL), 3M sulfuric acid (25 mL), 80% Ethanol in water (-20 mL) (25 mL) ocedure ring week one you will generate the Grignard reagent (Part A) and react it with the ester (Part During the second week, you will protonate the alkoxide ion, isolate the alcohol, and purify alcohol by recrystallization. ek 1: Part A - Preparation of the Grignard reagent: phenylmagnesium bromide. Br MgBr Et2O Mgo phenylmagnesium bromide aka "phenyl Grignard" bromobenzene

Answer 1

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