Question

EXPERIMENT S: THE GRIGNARD REACTION Pre-lab assignments are found at the end of the lab manual Review the sections in Chapter 10 in the textbook dealing with organometalic reagents. As will be evident in this and chapters, Grignard reagents play a commanding role in organic synthesis, adaptable to the preparation of a large ater variety of functional systems, and comprise one of the major uses of alkyl halides. This experiment involves a synthesis diphenylmethanol using phenylmagnesium bromide and benzaldehyde Reaction of a halide and magnesium occurs on the metallic surface and is formally an oxidation of the metal. The reaction is usually carried out in ether solution. The ether solvent functions as a Lewis base, solvating the Grignard tfall in preparing a ent and permitting it to diffuse away from the metal. As stated in Chapter 10, the major pi Grignard compoundis the presence of alcohol or any other active hydrogen (proticl compound, as and wastes the reagent, and may also seriously complicate its formation, since the magnesium salt that forms from reaction with a proton source is often much less soluble and can coat the surface of the metal, preventing reaction of the alky halide. Experimental The glassware shown in this picture has been dried in an oven and should be taken directly from there. CaClh drying tube 1. Assemble the apparatus as shown in the picture: fit the round-bottom flask with a Claisen adapter; fit the Claisen adapter with a condenser a glass stopper; and fit the condenser with a drying tube filled with blue desiccant". Ensure that all joints are fitted well and all clamps are secure water out amp water in chemicals, Run a gentle stream of tap water through the condenser amp Claisen 2. In the clean and dry 50 ml Erlenmeyer flask (from the oven), make u solution of 1.8 ml of bromobenzene in 9 ml of dry (anhydrous) ether u lamp round-bottom stir bar Stir plate pport tand 35 Glassware Set-Up

Answer 1

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