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How can a cell gain energy while folding proteins in the periplasm?

How can a cell gain energy while folding proteins in the periplasm?

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The periplasmic chaperon found to be different from cytoplasmic chaperone. periplasm is devoid of ATP which generally required for proper folding conformations achieved by the proteins. There are two proteins required for the protein folding that are protein disulphide isomerases (Dsb proteins), which catalyse disulfide-bond formation, and peptidyl-prolyl isomerases (PPIase), which catalyse cis-trans isomerization of peptidyl bonds.

The maintanence of thiol isomerase's in reduced state is the rate limiting step which in turn energised by thioredoxin/thioredoxin reductase system in the cytoplasm as a source of reducing equivalents.

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