Question

These problems relate back to the first step mechanism showed. It is a multi step question so your answer will be appreciated

ssignment-2 for Chem C342 (Hon) Total points: 50 points Assignment due: Monday, April 19, 2019 (No Excuse 1. Meclizine is an antiemetic. It he Ips p revent or at least lessen the vomiting associated with Meclizine can be synthesized by the following motion sickness, including seasickness. series of reactions: 20 pts Cl он CI CI Cl CH3 Meclizine carboxyl group to this functional group? Show the chemical equation with appropriate reagent(s) and conditions here. a) Name the functional group in (A). What reagent is most commonly used to convert a s AlCI. Name the type of reaction that occurs in this step. The the orientation of the new group para to the chlorine atom of you were not told the orientation of the new group. Would you eroduct shown here has the hlorobeed it to be ortho, meta, or para to the chlorine atom? Explain. c) What set of reagents can be used is step-3 to convert the C-o group to an -NH: group? Show all the chemical equations with appropriate reagent(s) and conditions here unreactive to nucleophiles such as the 1° amine in this step. Ethylene oxide, however, is an exception to this generalization. What is it about ethylene oxide that makes it so reactive with nucleophiles? d) The reagent used in Step-4 is the cyclic ether, ethylene oxide. Most ethers are quite e) What reagent can be used in step-5 to convert each primary alcohol to a primary halide? Show your chemical equation with appropriate reagent(s) and conditions here. 0 Step-6 is a double nucleophilic displacement. Which mechanism is more likely for this reaction, SNI or SN2? Explain. Test your cumulative knowledge of the reactions learned in this course by completing the following chemical transformations. Note: Most will require more than one step. 30 pts 2. a) Only carbon source

Answer 1

댜 C) (ii) Naghy hale de so preferes SN2