Question

A mutation in human ATPase 6 (which corresponds to E. coll subunit a) from leucine to arginine at position 156 may allow the movement of protons across the membrane, but not the rotation of the ring of c subunits. How might this possible mechanism affect the function of ATP synthase? Choose two answers Proton binding to subunit c would not be impaired. There would be an uncoupling of proton translocation and ATP synthesis. ATP hydrolysis coupled to proton transport out of the matrix would increase. There would be no net effect on the overall function of ATP synthase. The c ring would become uncoupled from the y and e subunits.

pls help!!

Answer 1

Option 2nd is right b ecause The F- ATPase (or F1F0 ATPase ) and V ATPase (or V1 V0 ATPase ) are both made up of two linked complexes, V1 complexes ( c subunit ) --- synthesis or hydrolyse the ATP and F0 or V0 complex that form pore for proton translocation.

so c subunit mutation causes no translocation of proton across transmembrane and THUS ATP synthesis will not occur,