Question

Label the following as either proto-oncogene, oncogene or tumor suppressor 3. A gene that initiates apoptosis when DNA damage occurs a. b. A gene that initiates the transition from G1 to S phase A gene that inhibits the transition from G1 to S phase c. d. A gene that promotes cell growth, combined with a hyperactive promoter How would methylation of the promoter of the gene in question 3c affect the cell? Be specific using what you know about the cell cycle 4. would you expect the same for gene 3 a. If you developed a cancerous skin lesion from overexposure to UV radiation and then had a child. Would this child also have skin cancer? Explain your answer. 5.

Answer 1

1. Genes that initiates DNA damage ar tumor suppressor gene. Tumor Suppressor genes such as ATM genes.
2. A gene that initiates the transition from G1 to S phase is a tumor suppressor gene. Tumor suppressor gene RB gene phosphorylates the E2F.
3. Azeem that affects the transition from G1 to S phase is a tumor suppressor gene p53 gene.
4. A gene that promotes cell growth when combined with the hyper active promoter is called proto-oncogenes which are converted into oncogenes.