Question

1. (6pts) Please circle whether you AGREE or DISAGREE with the following statements and provide your reasoning: A. Whether a signal pathway leads to the activation of a downstream response depends on whether the last step in the pathway is an activating or inhibiting step AGREE or DISAGREE Reasoning B. Since phosphatases dephosphorylate proteins by removing phosphate groups, they deactivate those proteins. AGREE or DISAGREE Reasoning

Answer 1

A. Disagree; Because last step of a signal pathway may involve either an inhibitory or activating enzyme and thus in case of inhibition of an inhibitory enzyme the downstream response will be positive while in case of activating enzyme the inhibition will lead to negative outcome.

B. Disagree; Again the reason is same. In case of dephosphorylation of an inhibitory enzyme the response will be positive while in case of dephosphorylation of an activating enzyme will lead to a negative outcome.