How does BPG, or 2,3-biphophoglycerate produce the shift in the oxygen bunding curves shown? (BPG works to effect the binding of oxygen to hemoglobin) Circle the correct choice. a) BPG binds to the R...

Question 1

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How does BPG, or 2,3-biphophoglycerate produce the shift in the oxygen bunding curves shown? (BPG works to effect the binding of oxygen to hemoglobin) Circle the correct choice.

a) BPG binds to the R state of hemoglobin tetramer.

b) BPG binds to the T state of hemoglobin tetramer.

c) BPG binds to the heme group, which blocks access to the oxygen

d) BPG oxidizes the iron (II) in the heme group to the iron (III), preventing oxygen from binding.
1.0 0 mM BPG 5 mM BPG 8 mM BPG in θ 0.5 0 4 8 12 16 po2 (kPa)

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Answer #1

Ans : (b) BPG binds to the T state of hemoglobin tetramer.

Explanation: 2,3-BPG binds to deoxyhemoglobin, it acts to stabilize the low oxygen affinity state (T state) of the oxygen carrier.It interacts with deoxygenated hemoglobin beta subunits and so it decreases the affinity for oxygen and allosterically promotes the release of the remaining oxygen molecules bound to the hemoglobin

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How does BPG, or 2,3-biphophoglycerate produce the shift in the oxygen bunding curves shown? (BPG works to effect the binding of oxygen to hemoglobin) Circle the correct choice. a) BPG binds to the R...

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How does BPG, or 2,3-biphophoglycerate produce the shift in the oxygen bunding curves shown? (BPG works to effect the binding of oxygen to hemoglobin) Circle the correct choice. a) BPG binds to the R...

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How does BPG, or 2,3-biphophoglycerate produce the shift in the oxygen bunding curves shown? (BPG works to effect the binding of oxygen to hemoglobin) Circle the correct choice. a) BPG binds to the R...