Question

1. How does a eukaryote like Candida auris gain its drug resistance?
2. As you can see, resistance is the theme to this exam. Pressure a microbe with a drug and it will be pushed to develop resistance. Those in Evolutionary Medicine have theories about this process. It has been suggested by some that if we remove the pressure (antimicrobial drug use), the microbes will lose their resistance. -Is there any evidence that supports their theory? -Is there a better way to stop drug resistance?

Answer 1

Candida auris is a fungus that is resistant to many many antifugal drugs.This anti fungal drug is mainly present at the hospital. The resistance in this fungus is due to overuse of antifungal drugs . These drugs are not only used in healthcare but also used in agriculture . The heavy use of this anti fungal developed multiple drug resistance in Candida.

Yes, it is correct to say that microbes have generated new mechanisms of resistance due to overuse of drugs. This lead to the development of drug resistance in microbes. The more the pressure in microbes, more is the resistance. This evolutionary mechanisms is according to the evolutionary theory of " Natural selection " given by Charles Darwin. According to this theory, variation exist in the individual of the population that allows them to adapt them to adverse environmental conditions. There are some steps that we can follow to stop drug resistance. For example , always complete the drug prescribed by the doctor, take less drug as much as possible.