If you were able to collect a solid sample from test tube #7, and completely dry the crystals, how could you test your product for purity? The test tube has salicylic acid and methyl alcohol
If you were able to collect a solid sample from test tube #7, and completely dry the crystals, how could you test your product for purity?
The test tube has salicylic acid and methyl alcohol
Homework Answers
Salicylic acid can be re-crystallized from methanol and water mixture. The test tube containing salicylic acid and methanol is treated with a small amount of water and heated when a homogenous solution results. The solution is then gradually cooled to room temperature when salicylic acid crystallizes out from the solution. The crystals are collected by vacuum filtration, washed and dried.
The purity of the compound obtained via crystallization can be ascertained in a number of ways. The simplest technique to ascertain the purity of a crystallized compound is to check the boiling point of the crystals. The melting point of pure salicylic acid is around 158.6ºC. If the crystals are pure, then the crystallized compound will melt over a sharp and narrow temperature, say between 157-159ºC. Impure compounds melt over a large temperature range.
The IR or the NMR spectrum of the crystallized compound can also be used to determine the purity of the crystals.
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If you were able to collect a solid sample from test tube #7, and completely dry the crystals, how could you test your product for purity? The test tube has salicylic acid and methyl alcohol
Pre-lab Questions: Importance A one-step preparation of aspirin from its precursor, salicylic acid, via an ester...
Pre-lab Questions:
Importance A one-step preparation of aspirin from its precursor, salicylic acid, via an ester formation illustrates one of synthetic organic chemistry's most important uses, making the drugs that treat all types of illnesses. OH HOOH Background Aspirin is a prodrug of salicylic acid, the actual active drug. A compound related to salicylic acid, salicin, was first isolated from willow bark in the mid 1700's, but willow-bark extract was used by the ancient Greeks as a treatment for pain...
Write out your separation scheme for this experiment. 1. Heat 75 mL of water to 90...
Write out your separation scheme for this experiment. 1. Heat 75 mL of water to 90 °C in a 250-mL beaker. 2. While the water is being heated, place 250 mg of salicylic acid, 1 drop of 85% phosphoric acid and 0.5 mL of acetic anhydride in a test tube. Add a boiling chip to the mixture and gently shake it in order to mix the reactants. 3. Heat the tube in the beaker of water at 85 - 90...
PREPARATION OF PHARMACEUTICALS - Fischer Esterification Reactions Q: Calculate the expected mass of both methyl salicylate and aspirin assuming 100% yield. EXPERIMENT7 PREPARATION OF PHARMACEUTICALS...
PREPARATION OF PHARMACEUTICALS - Fischer Esterification
Reactions
Q: Calculate the expected mass of both methyl salicylate and
aspirin assuming 100% yield.
EXPERIMENT7 PREPARATION OF PHARMACEUTICALS Fischer Esterification Reactions Almost 2500 years ago, physicians such as Hippocrates recommended that patients chew on the bark of the willow to alleviate pain. The active ingredient in willow bark was found to be salicin, a compound made of a molecule of salicyl alcohol bonded to a p-D-glucose molecule. In the stomach, the bond between...
PROCEDURE CAUTION!!! Nitric acid and sulfuric acid are strong and corrosive acids. For that reason, avoid...
PROCEDURE CAUTION!!! Nitric acid and sulfuric acid are strong and corrosive acids. For that reason, avoid inhaling its vapors or causing any contact with the skin or clothing. Wear your protective glasses at all times. Use the extractors to work with these acids. A. Nitration of methyl benzoate 1. Preparation of the reactants. In the extractor you will find a burette with concentrated sulfuric acid, a second burette with concentrated nitric acid, clearly identified. Familiarize yourself with the scales of...
For the nitration of methyl benzoate: a. Which product did you get? What evidence do you...
For the nitration of methyl benzoate:
a. Which product did you get? What evidence do you have for
this?
b. Was your product pure? What evidence do you have for this?
Explain your evidence.
c. Draw the mechanism for the product you got.
For the bromination of acetanilide:
a. Which product did you get? What evidence do you have for
this?
b. Was your product pure? What evidence do you have for this?
Explain your evidence.
c. Draw the mechanism...
Place 3.0 g of salicylic acid in a 125-ml Erlenmeyer flask. Carefully add, stirring constantly, 6...
Place 3.0 g of salicylic acid in a 125-ml Erlenmeyer flask. Carefully add, stirring constantly, 6 mL of acetic anhydride, followed by 10 drops of concentrated sulfuric acid. Swirl the contents of the flask so that the reactants are thoroughly mixed. Stopper the flask with a one- hole cork fitted with an inverted Pasteur pipet to prevent condensation of water in the reaction flask during heating on the steam bath. Heat the flask in a boiling-water or steam bath for...
1.) What would the product be if you oxidized a tertiary alcohol? A.) Ketone B.) Aldehyde...
1.) What would the product be if you oxidized a tertiary
alcohol?
A.) Ketone
B.) Aldehyde
C.)Carboxylic Acid
D.) No reaction
2.) What would the FULLY oxidized product of a primary alcohol
be?
A.) No reaction
B.) Carboxylic Acid
C.) Aldehyde
D.) Ketone
3.) Which types of alcohol can be oxidized? Choose all that
apply.
A.) Quaternary
B.) Primary
C.) Secondary
D.) Tertiary
4.) the Ethanol standard in test tube 3 will have a final
concentration of _____%(v/v) ethanol.
5.)...
1) Which reactant, salicylic acid or acetic anhydride, is in excess? Show your work. 2) If you we...
1) Which reactant, salicylic acid or acetic anhydride, is in
excess? Show your work.
2) If you were to use 3.17 g of starting material, how much
product would you expect? Again, show your work.
3) Why is phosphoric acid added to the reaction?
4) A small amount of water is added at the end of the reaction
to react with the excess acetic anhydride. Show a balanced equation
for that reaction.
5) Explain the purpose of the FeCl3 test...
Post-Lab Questions HW1. Solid methyl trans-cinnamate is (basic/ acidic/ neutral)? Solid trans-cinnamic acid is (basic/ acidic/...
Post-Lab Questions HW1. Solid methyl trans-cinnamate is (basic/ acidic/ neutral)? Solid trans-cinnamic acid is (basic/ acidic/ neutral)? If you could not perform an FT-IR, GC-MS, or 'H/C NMR, what two things could you do in the lab to validate the presence of the product upon isolation given that both the starting material and product are white solids? 2. HW2. A wash removes undesired materials from the phase the product is in to another phase. An extraction removes the desired product...
the weight if the initial product was 3.4 grams of methyl benzoate. Who |o yald foR 3.91SSg st prodoc...
the
weight if the initial product was 3.4 grams of methyl
benzoate.
Who |o yald foR 3.91SSg st prodoct nd product 2.14143 EXPERIMENTAL PROCEDURE SAFETY WEAR nitrile gloves for this experiment. The nitrating moture of sulfuric acidnitric acid (1:1) is a very strong acid system. Do not allow it to come in contact with your skin or clothing. It will cause acid burns if it comes in contact with your skin (and holes an your clothes). Wash any affected area...
Pre-lab Questions:
Importance A one-step preparation of aspirin from its precursor, salicylic acid, via an ester formation illustrates one of synthetic organic chemistry's most important uses, making the drugs that treat all types of illnesses. OH HOOH Background Aspirin is a prodrug of salicylic acid, the actual active drug. A compound related to salicylic acid, salicin, was first isolated from willow bark in the mid 1700's, but willow-bark extract was used by the ancient Greeks as a treatment for pain...
PREPARATION OF PHARMACEUTICALS - Fischer Esterification
Reactions
Q: Calculate the expected mass of both methyl salicylate and
aspirin assuming 100% yield.
EXPERIMENT7 PREPARATION OF PHARMACEUTICALS Fischer Esterification Reactions Almost 2500 years ago, physicians such as Hippocrates recommended that patients chew on the bark of the willow to alleviate pain. The active ingredient in willow bark was found to be salicin, a compound made of a molecule of salicyl alcohol bonded to a p-D-glucose molecule. In the stomach, the bond between...
PROCEDURE CAUTION!!! Nitric acid and sulfuric acid are strong and corrosive acids. For that reason, avoid inhaling its vapors or causing any contact with the skin or clothing. Wear your protective glasses at all times. Use the extractors to work with these acids. A. Nitration of methyl benzoate 1. Preparation of the reactants. In the extractor you will find a burette with concentrated sulfuric acid, a second burette with concentrated nitric acid, clearly identified. Familiarize yourself with the scales of...
For the nitration of methyl benzoate:
a. Which product did you get? What evidence do you have for
this?
b. Was your product pure? What evidence do you have for this?
Explain your evidence.
c. Draw the mechanism for the product you got.
For the bromination of acetanilide:
a. Which product did you get? What evidence do you have for
this?
b. Was your product pure? What evidence do you have for this?
Explain your evidence.
c. Draw the mechanism...
Place 3.0 g of salicylic acid in a 125-ml Erlenmeyer flask. Carefully add, stirring constantly, 6 mL of acetic anhydride, followed by 10 drops of concentrated sulfuric acid. Swirl the contents of the flask so that the reactants are thoroughly mixed. Stopper the flask with a one- hole cork fitted with an inverted Pasteur pipet to prevent condensation of water in the reaction flask during heating on the steam bath. Heat the flask in a boiling-water or steam bath for...
1.) What would the product be if you oxidized a tertiary
alcohol?
A.) Ketone
B.) Aldehyde
C.)Carboxylic Acid
D.) No reaction
2.) What would the FULLY oxidized product of a primary alcohol
be?
A.) No reaction
B.) Carboxylic Acid
C.) Aldehyde
D.) Ketone
3.) Which types of alcohol can be oxidized? Choose all that
apply.
A.) Quaternary
B.) Primary
C.) Secondary
D.) Tertiary
4.) the Ethanol standard in test tube 3 will have a final
concentration of _____%(v/v) ethanol.
5.)...
1) Which reactant, salicylic acid or acetic anhydride, is in
excess? Show your work.
2) If you were to use 3.17 g of starting material, how much
product would you expect? Again, show your work.
3) Why is phosphoric acid added to the reaction?
4) A small amount of water is added at the end of the reaction
to react with the excess acetic anhydride. Show a balanced equation
for that reaction.
5) Explain the purpose of the FeCl3 test...
Post-Lab Questions HW1. Solid methyl trans-cinnamate is (basic/ acidic/ neutral)? Solid trans-cinnamic acid is (basic/ acidic/ neutral)? If you could not perform an FT-IR, GC-MS, or 'H/C NMR, what two things could you do in the lab to validate the presence of the product upon isolation given that both the starting material and product are white solids? 2. HW2. A wash removes undesired materials from the phase the product is in to another phase. An extraction removes the desired product...
the
weight if the initial product was 3.4 grams of methyl
benzoate.
Who |o yald foR 3.91SSg st prodoct nd product 2.14143 EXPERIMENTAL PROCEDURE SAFETY WEAR nitrile gloves for this experiment. The nitrating moture of sulfuric acidnitric acid (1:1) is a very strong acid system. Do not allow it to come in contact with your skin or clothing. It will cause acid burns if it comes in contact with your skin (and holes an your clothes). Wash any affected area...
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