Question

1. Consider the synthesis of the following amino acids:

a) write all the steps for the synthesis of valine starting with propane, using the HVZ reaction to make a bromo-acid, which is subsequently laminates.

b)Write all the steps for the synthesis of leucine starting with isobutane and using the Gabriel-Malonic Ester reaction. Also, consider: I)how would the L-enantiomer of the amino acid be isolated from the racemic mixture resulting from the above reactions. ii) what would the mechanism be for each of the steps.

Answer 1

Me '- NaDEt CH-C-D reachon Valine Now K. DNaoGA Laune

Resolu (h.erng nu, edua anu, u o @elda- racen uと Com mon arid - anm'no au ok 50:50 Diceteseomc