Question

3. See Chemistry Around Us 20.3 Cases of antfreeze poisoning are often treated by using a compettive inhibitor of the enzyme alcohol dehydrogenase a Two compounds that are likely to react with this enzyme are Models and b Fill in the boxes in the diagram with the numbers of the correct models Bubstrace (poson) Acchol Denydrogenase Nomal Product reatment) c. Describe the relationship between Models 3 1 and 3 3 3 2 and 33 d. Increasing the concentration of one of these compounds will cause a decrease in competitive inhibition Which one is it? e Describe the difference between this inhibitor process and that of a noncompettive inhibitor 3 2 3.3 C H Index Il Exercise 12 345

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Answer 1

3. a) Two compounds that are likely to react with enzyme are models 3.1 and 3.2

b)

Substrate (poison) is 3.3

                                    Alcohol dehydrogenase                    Normal Product (3.1)

Inhibitor (treatment) is 3.2

c) Relationship between 3.1 and 3.3

Here in model 3.1 is the hydroxy acetaldehyde is the product which formed by dehydrogenation of substrate of 3.3 which is glyoxal or ethylene glycol.

Relationship between 3.2 and 3.3

In place of 3.3 we can use 3.2 which is a competitive inhibitor of glyoxal and inhibit the formation of 3.1. So 3.2 is the inhibitor and 3.3 is the substrate for same enzyme alcohol dehydrogenase.

d) Increase in the concentration of substrate 3.3 will decrease in the competitive inhibition. Along with that if we also increase the concentration of product 3.1 then also competitive inhibition will decrease.

e) The difference in the process of competitive with noncompetitive inhibition is that the inhibitor has structural resembles with the substrate but there is no structural similarity in non competitive process. Competitive inhibitor binds to the active site of enzyme replacing substrate but there is altogether binding at binding site during noncompetitive inhibition.