Question

5. Bicyclic methyl ester 3 can be prepared from (E)-nona-6,8-dienal by a Horner Wadsworth-Emmons reaction and subsequent heating to induce an intramolecular Diels-Alder reaction. Draw the necessary HWE reagent (what is the phosphorous ylide?) as well as a transition state for the DA reaction. Is the final product 3 an endo or an exo cycloadduct? H. H 0 heat 3

Answer 1

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