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What defect in cardiac energy metabolism would appear to be the basis of the high-output cardiac failure observed?

What defect in cardiac energy metabolism would appear to be the basis of the high-output cardiac failure observed?

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Answer #1
  • Most of the Heart failures leads to contractile dysfunction and progressive LV remodeling.
  • In later stages, there would be a downregulation in fatty acid oxidation
  • Increased glycolysis and glucose oxidation
  • Decreased respiratory chain activity
  • aimpaired reserve for mitochondrial oxidative flux.
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