Question

1. In Grave's Disease, hyperthyroidism is produced by an IgG that causes prolonged activation of the TSH receptors and results in excessive secretion of T and T. Explain why the negative feedback mechanism does not work in this disease. Reference an internet source (URL). journal article or book (5 points). 2. Chromatographic assay reveals that the total amount of Tj in the blood is 100 ng. You find that the various bound forms of the hormone are: Tythe,-0.5% T, ~ albumin-12 % T3-TBG-69 % and T3-pro-albumin 18.5 % Target tissue: heart whose Bmax of T, receptors 76 fmol of T, receptor/mg protein ( 1 mol 10.15 mol), where you have 100 g protein (total protein of which T3 receptors makes only a tiny fraction) in your heart assay. MW 68 kDal - 68,000 g/mol [Dasmalopatra et al Receptor, 2(4):213-223, 1992]. This reference is only for the MW of T, receptor, and not for the solution to this question. Note: You won't need the MW of T, because you already have the amount in g. This is another conceptual question. So, don't get all caught up in equations. In fact, don't use the equations I provided in lecture, 6MemR. If you had freshman chemistry or physics (and al of you should have), then you can solve the following: Calculate the amount (in g) of available T and its receptar (also in g). How do the 2 amounts compare? Will Bmax be reached (10 points)? ( O . ! ntive ferdbaçk mchanism doe not horK in gra disea

Answer 1

Solution :-1

The Grave's sickness is an immune system issue. Enlistment of hyperthyroidism i.e. lifted levels of thyroid hormone with low levels of TSH alongside T3 and T4 happen in this infection. As indicated by pre-clinical and clinical inquires about, it has been discovered that the patient with Grave's infection produces antibodies which themselves tie to the TSH-receptors on the cells hence up-directing arrival of T3 and T4. Since the body can't distinguish among self and non-self cells, these antibodies more than once tie to the TSH-receptors and therefore prompt over-discharge of T3 and T4. Further, since the circulatory levels of thyroid hormone are expanded under this situation, the pituitary organ continues discharging more measure of TSH because of official of antibodies on the TSH-receptors. This disables the negative input circle restraint system. Thusly, the patient is typically determined to have lifted levels of thyroid hormone and low circulatory levels of TSH.

Solution:2

Solukion:- Due t uestion T3.in bleed -1。 T (fte)-05 So that rhen 3 mar (S so thal tho amount 4 (nリ1n = 100 μ 2. So Hhal 2h 0