Why is the formation of a substitution product involving displacement of water by attack of bisulfate upon the protonate...
Why is the formation of a substitution product involving displacement of water by attack of bisulfate upon the protonated alcohol not a reaction of concern in the elimination reaction?
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Why is the formation of a substitution product involving displacement of water by attack of bisulfate upon the protonate...
9) What are we removing with the water wash? Why don’t we just add the sodium...
9) What are we removing with the water wash? Why don’t we just
add the sodium bicarbonate directly to the reaction mixture instead
of doing a water wash? 10) Provide the results of the silver
nitrate test.
Introduction Alkyl halides can be prepared from alcohols by reactions with hydrogen halides (HCl, HBr, or HI) via nucleophilic substitution. In this type of reaction, the nucleophile displaces a leaving group from a carbon atom of an organic substrate (here the alcohol once...
Mechanism.Provide a mechanismto account for formation of the product of thefollowing Electrophilic Aromatic Substitution reaction. Mechanism....
Mechanism.Provide a mechanismto account for formation of the
product of thefollowing Electrophilic Aromatic Substitution
reaction.
Mechanism. Provide a mechanism to account for formation of the product of the following Electrophilic Aromatic Substitution reaction. D. OX Reactions. Please complete the following reaction schemes. Molaro NH2 FeCl3 H300 OCH3 H2CO OCH3
Devise a detailed mechanism for formation of the major product of the elimination reaction below.
Devise a detailed mechanism for formation of the major product of the elimination reaction below. Draw curved arrows to show electron reorganization for the mechanism step below. Make the ends of your arrows specify the origin and destination of reorganizing electrons. Devise a detailed mechanism for formation of the major product of the elimination reaction below. Draw curved arrows to show electron reorganization for the mechanism step below. Make the ends of your arrows specify the origin and destination of reorganizing electrons. Devise a...
OCHEM CHAPTER 26 A clever new method of peptide synthesis involving formation of amide bond by...
OCHEM CHAPTER 26 A clever new method of peptide synthesis
involving formation of amide bond by reaction of an alpha-keto acid
with an n-alkylhydroxylamine, The reaction is thought to occur by
nucleophilic addition of N-alkylhydroxylamine to the keto acid as
if forming an imine followed by decarboxylation and elimination of
water. Show the mechanism. Please show the mechanisms, and I WILL
RATE
1 OH DMF R + N R + -R2 + H CO2 H20 20 ZI OH
b) When the following deuterated compound reacts under the same conditions, the rate of formation of...
b) When the following deuterated compound reacts under the same conditions, the rate of formation of the substitution product is unchanged, but the elimination rate is slowed by a factor of 7. Why is the elimination slowed, but substitution unchanged? D3C-CH-CD3 + KOH - D2C=CH-CD3 + D3C-CH-CD3 Br alcohol OH (20) 7. Which reaction of the following pairs will take place more rapidly? a) CH, CH, CH, Br + CH, OH — CH, CH, CH, Br + CH30 — b)...
Of the 3 compounds below, one undergoes hydrolysis rapidly in water, another undergoes hydrolysis upon heating,...
Of the 3 compounds below, one undergoes hydrolysis rapidly in water, another undergoes hydrolysis upon heating, and the third is stable even in boiling water. Explain these results, which one does not react, and show the mechanism (Spl) for the formation of the alcohol product for the compound that only reacts when heated. CH3
Question 17-17 What is the major organic product obtained from the following reaction? H2SO4 но он...
Question 17-17 What is the major organic product obtained from the following reaction? H2SO4 но он 3 но он но Question 17-30 Which of the following best describes the key mechanistic steps in the esterification of a carboxylic a upon treatment with an alcohol in the presence of a strong acid? a. addition followed by elimination b. substitution followed by addition c. elimination followed by addition d. addition followed by decarboxylation
Which of the following statement is correct about the mechanism of hemiacetal and acetal formation? A....
Which of the following statement is correct about the mechanism of hemiacetal and acetal formation? A. In the hemiacetal formation mechanism, the oxygen on the alcohol uses its lone pair to "attack the carbonyl carbon before the protonation of the carbonyl oxygen B. The carbocation formation is not favored during the hemiacetal formation mechanism, this is why hemiacetal are generally unstable and very reactive C. In the acetal formation mechanism, hydrolysis of water to the hemiacetal carbon center occurs as...
(16) 6. Deuterium is the isotope of hydrogen of mass number 2, with a proton and...
(16) 6. Deuterium is the isotope of hydrogen of mass number 2, with a proton and a neutron in its nucleus. It is often designated 2H, or D. We have seen that the chemistry of deuterium is nearly identical to the chemistry of hydrogen, except that the C-D bond is slightly (1.2 kcal/mole) stronger than the C-H bond. a) Propose (show) a mechanism to explain each product in the following reaction: CH2-CHCH CH CH CH3 CH3 CH CH3 KOH +...
5) Iodine is a better leaving group than bromine. But iodine is a better nucleophile than bromine. Why is that? Introdu...
5) Iodine is a better leaving group than bromine. But iodine is
a better nucleophile than bromine. Why is that?
Introduction Alkyl halides can be prepared from alcohols by reactions with hydrogen halides (HCI, HBr, or HI) via nucleophilic substitution. In this type of reaction, the nucleophile displaces a leaving group from a carbon atom of an organic substrate (here the alcohol once protonated). Both electrons of the new bond to the carbon are provided by the nucleophile while the...
9) What are we removing with the water wash? Why don’t we just
add the sodium bicarbonate directly to the reaction mixture instead
of doing a water wash? 10) Provide the results of the silver
nitrate test.
Introduction Alkyl halides can be prepared from alcohols by reactions with hydrogen halides (HCl, HBr, or HI) via nucleophilic substitution. In this type of reaction, the nucleophile displaces a leaving group from a carbon atom of an organic substrate (here the alcohol once...
Mechanism.Provide a mechanismto account for formation of the
product of thefollowing Electrophilic Aromatic Substitution
reaction.
Mechanism. Provide a mechanism to account for formation of the product of the following Electrophilic Aromatic Substitution reaction. D. OX Reactions. Please complete the following reaction schemes. Molaro NH2 FeCl3 H300 OCH3 H2CO OCH3
OCHEM CHAPTER 26 A clever new method of peptide synthesis
involving formation of amide bond by reaction of an alpha-keto acid
with an n-alkylhydroxylamine, The reaction is thought to occur by
nucleophilic addition of N-alkylhydroxylamine to the keto acid as
if forming an imine followed by decarboxylation and elimination of
water. Show the mechanism. Please show the mechanisms, and I WILL
RATE
1 OH DMF R + N R + -R2 + H CO2 H20 20 ZI OH
b) When the following deuterated compound reacts under the same conditions, the rate of formation of the substitution product is unchanged, but the elimination rate is slowed by a factor of 7. Why is the elimination slowed, but substitution unchanged? D3C-CH-CD3 + KOH - D2C=CH-CD3 + D3C-CH-CD3 Br alcohol OH (20) 7. Which reaction of the following pairs will take place more rapidly? a) CH, CH, CH, Br + CH, OH — CH, CH, CH, Br + CH30 — b)...
Of the 3 compounds below, one undergoes hydrolysis rapidly in water, another undergoes hydrolysis upon heating, and the third is stable even in boiling water. Explain these results, which one does not react, and show the mechanism (Spl) for the formation of the alcohol product for the compound that only reacts when heated. CH3
Question 17-17 What is the major organic product obtained from the following reaction? H2SO4 но он 3 но он но Question 17-30 Which of the following best describes the key mechanistic steps in the esterification of a carboxylic a upon treatment with an alcohol in the presence of a strong acid? a. addition followed by elimination b. substitution followed by addition c. elimination followed by addition d. addition followed by decarboxylation
Which of the following statement is correct about the mechanism of hemiacetal and acetal formation? A. In the hemiacetal formation mechanism, the oxygen on the alcohol uses its lone pair to "attack the carbonyl carbon before the protonation of the carbonyl oxygen B. The carbocation formation is not favored during the hemiacetal formation mechanism, this is why hemiacetal are generally unstable and very reactive C. In the acetal formation mechanism, hydrolysis of water to the hemiacetal carbon center occurs as...
(16) 6. Deuterium is the isotope of hydrogen of mass number 2, with a proton and a neutron in its nucleus. It is often designated 2H, or D. We have seen that the chemistry of deuterium is nearly identical to the chemistry of hydrogen, except that the C-D bond is slightly (1.2 kcal/mole) stronger than the C-H bond. a) Propose (show) a mechanism to explain each product in the following reaction: CH2-CHCH CH CH CH3 CH3 CH CH3 KOH +...
5) Iodine is a better leaving group than bromine. But iodine is
a better nucleophile than bromine. Why is that?
Introduction Alkyl halides can be prepared from alcohols by reactions with hydrogen halides (HCI, HBr, or HI) via nucleophilic substitution. In this type of reaction, the nucleophile displaces a leaving group from a carbon atom of an organic substrate (here the alcohol once protonated). Both electrons of the new bond to the carbon are provided by the nucleophile while the...
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