Solution:
In the given conversions, the missing reactants (alkenes) are given below.
1) Hydroboration-oxidation of alkene form an alcohol at terminal double bonded carbon.
2) Addition of Br2 on trans alkene forms meso compound.
3) Addition of Br2 on cis alkene forms d, l- mixture.
1. Predict the starting material that will provide the written product (3 x 2 = 6 points): ? 1. BH 2. H,O, NaOH OH ? »...
1. PREDICT THE PRODUCT: Provide the structure of the major product expected from the following reactions or reaction sequences. Make sure you account for any regio- and/or stereochemistry! (24 pts.) H2O 1. Hg(OAC), CH, OH 2. NaBH H2SO4 H20 1) BH-THF 2) H202, KOH HBr Bry, H2O HBr ROOR 1. BH3-THF 2. H2O2, NaOH H20, H2SO4 1. NaNH2 H2 H-CEC-CH2 CH2 CH3 2. CH CH Br Lindlar cat 1. Sia BH-THF 2. H2O2, H2O
predict the product 1. (12 pts) Predict the product for the following transformation. OH OH 유 1.H2OH' HO 2. KH, 18-c-6, THF OH OH Br Ph OH OBn O 1. H20, H HO 2. O 、Me , cat. H+ Me 1. (12 pts) Predict the product for the following transformation. OH OH 유 1.H2OH' HO 2. KH, 18-c-6, THF OH OH Br Ph OH OBn O 1. H20, H HO 2. O 、Me , cat. H+ Me
3. Provide the product, starting material, or reagents necessary to complete the reaction. OEt NaOH 2 starting materials OH Cl
draw the major product 1) BH, in THE - 06/26 2) "C/SM NaOH(aq) 30% H,O,/1h [Na/OOH H.C. Brown. JACS, 1959, 81, 247, (05 yield) (ul CH.CH CH,CI CH.CH CH.CH In CHCI,/ CHCh 130 min OS V 467(80-86% yield) HO-B Bry/H, DMSO THO-Br B /H, DMSO Boy (eld" Bry/CH, OH - L Сн,он Cl/H, HỆ CHI 15 20 C. OS I 158 70-73 yield) CI/H, но с Bry/H,0 THOB] CI/H,O Bry/ -78 °C in CH, CI, 76h (934 yield) (kk) Cl/H20...
What is the major product of the following reaction? NAOH heat X X ger K OH o The best way to synthesize the following amine is: H2N- 1. HNO3 H2SO4 2. Fe, HCI 3. NaOH 1. NaCN Br 2. LiAH, 3. H0 1. Bry. FeBrz 2. NaN 3. H. Ni 1 NBS hr 2 NaNH NHI What is the major product of this reaction! CHU, Hy0°.H20 OH -OH och OH
b. 4. Predict the major product of the following reaction. BH, H,O. HO OH
19. (Spts total) Match the reagents with the product if the starting material is: Reagent Product Br Br, HO I) RCO H 2) H,O Br он КМпО. NaOH, cold HBr, ROOR A X Он ) Hg(OAc)p.H;O X2) NaBH Br 1) BHy THF 2) H2O2, NaOH "Вг F. он Н.Pt "Вг G. он ) O 2) DMS "ОН Он HBr X OH Br2
15. (15 points total, 5 points each) For 3 of the 4 reaction sequences below, predict the final product. For partial credit, show the product from the first reaction as well. 1) CH3ONa 2) H,O, H,SO, A 3) Ph P=CH2 1) LDA (1.05%) 3) BH 4 HỎ, NaOH. (forms a mixture of diastereomers) AICI: 2) HNO3, H2SO4 3) Bra, FeBrz 1) Br, hv 2) Mg, ether 3) Yo 4) Bry, FeBrz 3/5
3. Predict the products: H, Pdc 1. BH 2. H,O, OH 1.0, 3. DMS H2SO4 100°C H2 Pd/CaCO3. quinoline کو کہا که } Brz LI, CH NH2 H, Pd/C
PREDICT THE PRODUCT OF THE FOLLOWING Sia BH H₂C -C C-H 2. H₂O2, OH 1, ㅋ