2. Determine the structures of A and B in the following sequence of trans formations. Determine the configurations (R o...
1. Determine the structures of A, B, C and D in the following sequence of transformations. Determine the configurations (R or S) of the stereocenters, where applicable. ОН TSCI, MeSNA MeOH A CHEI acetone B UN SAC C DMF (R) Py
18,19
18. (2 Marks) Convert the following Lewis structures into skeletal drawings. b) a) 19. (3 Marks) Assign R,S configurations to each indicated stereogenic centre in the molecules below. он CH2NH2 он norepinephrine trans-cyclopentane-1,2-diol
18. (2 Marks) Convert the following Lewis structures into skeletal drawings. b) a) 19. (3 Marks) Assign R,S configurations to each indicated stereogenic centre in the molecules below. он CH2NH2 он norepinephrine trans-cyclopentane-1,2-diol
For each of the following structures: (a) Give the IUPAC name. (b) Identify the leaving group. (c) Identify the degree of substitution of the carbon bearing the leaving group. (d) Identify the same carbon as (R) or (S), if applicable. (e) Give the product(s), if any of reaction with NaOH and with NaOCH3. (1) Identify the same carbon as in (c) and (d) in the product as (R) or (S), if applicable. (g) Choose the most appropriate solvent to facilitate...
Diethyl malonate can be prepared by the following reaction sequence. Draw the structures of each of the missing intermediates in the boxes provided. 4. |сH,сH он. 1. Bry PBr3 OH 2. H2O не На NaCN HSO NC CH CH-OH осH сH, CH2 HQ, heat CH2 HCl OEt Et0 How would you prepare each of the following compounds using either an acetoacetic ester synthesis or a malonic ester synthesis? Show all intermediate structures and all reagents 5. COOH
3. Draw structures of the compounds A and B and indicate relative configuration of the stereocenters (where applicable) using wedges and dashes. OH N1 A 1. X 2. H30* 1. OsO4 2. NaHSO, - в HBr A (CH3CH2)2COK (CH3CH2),COH B CHCE N°49 ano C2H5= Na/NH3 () A pesan, C2H5 — -33°C d. CH2Cl2, 20°C
please answer d e f g
For each of the following structures: (a) Give the IUPAC name. (b) Identify the leaving group. (c) Identify the degree of substitution of the carbon bearing the leaving group. (d) Identify the same carbon as (R) or (S), if applicable. (e) Give the product(s), if any of reaction with NaOH and with NaOCH3- (1) Identify the same carbon as in (c) and (d) in the product as (R) or (S), if applicable. (g) Choose...
3. Draw structures of the compounds A and B and indicate relative configuration of the stereocenters (where applicable) using wedges and dashes. vo.OH - 1. d 1. OsO4 + B 2. Hz0+ 2. NaHSO3 HBr A bo (CH3CH2)2COⓇK (CH3CH2)2COH > B H.C-= N °LⓇ. A. ^ . LOH C2H5= Na/NH3 () NH, ch. C2H5 - 2A- -33°C B CH2Cl2, 20°C
2. (4 pts) Assign (R) or (S) configurations to each of the following compounds. b) Всш CI NC H нш Он CH3
1) R'-MgBr in THF 2)H,o NaH Ho or OH PAA X2. H20 1) Hg(OAc)2, R'OH 2) NaBH4, NaOH, H20 Os0 NaHSO, H2O I) 2)CH, SCH HyIO HBr ROOR 1)BH3. THF 2)H202, NaOH, H2O Mg, THF PBr3 NaOH )OTHF 2) H30 CrOj. H,SO, 1) NaH 2)RXDMF "О-R DMF PCC DCM ) THF 2) H3O+ SOCI pyridine Li Hexanes
Predict the product of the following reaction sequence. (3 points) A Ph B Ph Ph- PH .Me 1. NaOH/H2O, heat 2. PhMgCI, THE 3. conc. H2SO4 с D Ph ОН Ph PH Ph1 Identify the product obtained from the following reaction sequence. (3 points) A 0 B o OH OH 1. NaOET, HOE HO HO 2. Å CO2H ii EIO ΟΕΙ C D 3. H20, HCI, A 4. H2SO4 HO CO2H