You are studyingHuntington's disease. You would like to identify the gene associated with huntington's, and so you look at the SNP profile of a large family with Huntington's. Below are the results The color box indicates the disease, while the elements below the box describe the SNPS.
a) Which SNPs are linked to the Huntington's disease gene? How did you know?
b) What is the orientation of the alleles in the FAther, and what is map distance between the SNP and the allele?
Homework Answers
a, Single-nucleotide polymorphisms(SNP) is a therapy for
trinucleotide repeat disease like Huntingtons disease(HD) two
huntington's alleles -normal and disease..The seven most abundant
haplotypes associated for 83% of HD chromosomes..HD mutations
randomly result of genetic trans-factors..SNP linkage with
trinucleotide repeat disease or for any two SNP sites it shows the
distant from the site of mutation..
b, To identify linkage between a particular SNP and CAG repeat of
the HTT mRNA,direct sequencing of each product identified the SNP
linkage.SNP Linkage for trinucleotide repeat disease or for any two
alleles of a gene in which SNP sites of interest are distant from
the site of mutation..
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size and sugar content starting from two parental varieties, “Sam’s
Giant (SG)” and “Sweet Baby Red (SBR)”. Your cross “Sam’s Giant”
and “Sweet Baby Red” and generate F1’s and then interbreed F1’s to
generate a series of F2 individuals and measure size and sugar
content in all of them. You determine the genotype at many
individual SNP markers, 5 of which (each on a different chromosome)
are shown below....
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computers are needed and thousands of loci can be tested for these
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dogs with white fur and dogs with black fur. If one type of SNP is
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identify variations that are associated with particular phenotypes,
they need techniques to evaluate the strength of the associations
so that they know which SNPs are closest to the locations of the
genes of interest. You will do a short exercise to help you
understand how this is done, followed by a chi-square test on one
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