Question

one and two

1. Aldehydes are more susceptible to nucleophilic attack than ketones. Explain. 2. Complete the following reaction scheme. РОCЬ pyridine 1. O3 NaBH 2. Me S E1OH (CH3)2CuLi SOC/2 H30*, heat 1. LIAIH NaCN Br 1. DIBALH acetone 2. Hа0 2. H30* 1. DIBALH 2. H30* HCN

Answer 1

1 Aldehydes are more susceptible to nucleophilic attack than ketones. Explain. Reactivity of carbonyl compounds (aldehyde/ketones) are depends on electrophilicity of carbonyl carbon. In ketones, carbonyl electrophilicity decreased by presence of alkyl/aryl group connected to it (Since, it posses +ve Indctive /mesomeric effect). In aldehydes one of the attached atom is Hydrogen and the corresponding carbonyl is less stabilized and more reactive 2 Complete the following reaction scheme. РОСЬ pyridine 1. O3 NaBH 2. Me S E1OH OH O (CH3)2CuLi OH SOC CI H3O, heat NH2 1. LIAIH NaCN Br CN 1. DIBALH acetone 2. H2O 2 H0 1 DIBALH 2. H 0 HCN CN Он