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Is lidocaine more soluble in aqueous base or aqueous acid? Is naproxen sodium (active ingredient in aleve) more soluble...

Is lidocaine more soluble in aqueous base or aqueous acid? Is naproxen sodium (active ingredient in aleve) more soluble in aqueous base or aqueous acid?

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Answer #1

Lidocaine is more soluble in aqueous acid than aqueous base. This is because of the similar polarity between lidocaine and the acid. We know that "like" dissolves "like" .

Naproxen sodium is lipid soluble basically. But also soluble in bases.

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