Worksheet 8.2 1. Predict the products: KMnO4, OH. cold 2. NaHSO3, H20 • Predict the mechanism and show the structur...
also show the mechanism and curved arrows for each mechanism 2. Predict the products for the reaction between le products for the reaction between Br, as well as Br/H, and the Alkenes listed below. rredict whether each reaction is syn- or anti-, Label the substrate, nucleophile and electrophile in each reaction. Substrate Structure Overall Reaction with Brz (with products) syn- or Overall Reaction with Bry/H20 (with products) anti- 3,3-dimethyl-1-1 butene 1-hexene styrene (phenylethene)
2. Predict the products for the following reactions of oxidation: 1. O3, DCM, -78°C 2. DMS 1. KMnO4, OH, heat KMnO4, OH. cold 2. H3O+ KMnO4, OH, heat Predict the mechanism for the reaction of ozonolysis and name all the intermediates:
OH H20 H2SO4 ОН H2, Pd (1) MCPBA (2) H30+ KMnO4 NaOH, cold
Wame: cold KMnO4, HO-or 1. OsO4 2. NaHSO3 1. mCPBA 2. H+, CH2OH, H2O 1. mCPBA 2. NaOCH3, H2O h.
Predict the products of the following reactions. 1. BH3 2. H2O2, OH CHCl3, KOH I-C1 (show the dipole in 1-C1, which is more electronegative?) 1. Hg(OAC)2, H2O 2. NaBHA 1. Hg(OAC)2, EtOH (not water) 2. NaBH4 m-CPBA H30+ 1. Os04 2. NaHSO3, H20
1.) KMnO4 cold dilute 2.) NaOH OH OH H "OH OH enantiomer enantiomer D KMnO4 warm conc. الت CH Cli enantiomer enantiomer B D
For each reagent, predict the major product(s). 1) MCPBA n 1) Os04 H OH HO H A. 2) H30* D. 2) NaHSO3/H2O 3. TOM B. Os04 (catalytic), NMO E. KMnO4, NaOH, cold H OH HO H HO HoT F. OsO4 (catalytic) c.) J OH 2) H30+ ????, NaOH <mo ? ????
(2) NaBH4 (2) H202 OH cold, dilute KMnO4 "ОН H,C H,C HCO,H H,O с-с CH CH2CH, CH,CH2CH Predict the major products of the following reactions, including stereochemistry where appropriate. (a) (R)-2-butanol + TsCl in pyridine c) cyclooctanol + CrO3/H2SO4 (e) cyclopentylmethanol + Na2Cr 01/H2SO4 (g) n-butanol + HBr (i) potassium t-butoxide + methyl iodide (k) cyclopentanol + H2SO4/heat (m) sodium ethoxide +1-bromobutane (b) (S)-2-butyl tosylate +NaBr (d) cyclopentylmethanol + CrOs pyridine HC cyclopentanol + HCI/ZnCl2 (h) cyclooctylmethanol + CH3CH2MgBr (G)...
Fill in missing reactants and show arrows HO OH 1. Os04 2. NaHSO3(aq) 1. Hg(OAc)2, H20 2. NaBH4 Na NH3 (1) Br. Br X.s. Br2 V B CC14 1. NaNH2 2. EtCI correct SCH I, CH,SH RISCH3 analogy to Bra, H₂O dil. H2SO4 HO
SAMSUNG 2.) Draw the products of the following six reactions. no," H20 Он, cold 1) BH3, T 2) H2O2 KMnO4, H2O +OOH,heat- then H,0° 1) Os04 pyridine 2) NaHS03,H20 1) Hg(OAc)2, THF, H20 1) 03 DCM, cold Provide the structure or fill in the missing spectral information. IR 1890 cm1 (sharp) 3005 cm (sharp) Integration 3 H Splitting