Question

For the essay that you pick, if there is a relevant pathway to outline, YOU MUST OUTLINE THE PATHWAY ON NEXT PAGE MARKED “PATHWAY" and then attempt to answer the problem. NO OUTLINE = N O POINTS stein and are analyzing a series of anti-hemostatic/hemostatic agents to "DEAD"(i.e. ZOMBIES) and a way to kill them. Your victims are a pool of hungry and poor administering the drug, you slash their wrists and also do isolated damage damage only) and observe how well their blood clots at and/or platelet plugs form at the to the blood vessel lining (tunica intima level. the following. Blood clotting in response to the tunica ashed wrists was normal. Please A) Upon administration of the drug BBA# 1, you observe intima damage was not initiated, while blood clotting in response to their sl identify and explain all of the potential MOLECULAR LEVEL) actions of BBAN1. (BE SPECIFIC AND DETAILED DOWN TO THE formation occurred, but the B) Upon administration of the drug BBA#5, you observe the following. Platelet plug platelet plug was not as strong or as of BB Please identify and explain all of the potential actions dense as it should be. A#5 on this SPECIFIC patient. (BE SPECIFIC AND DETAILED DOWN TO THE MOLECULAR LEVEL

Answer 1

A. The drug inhibits the enzyme cyclooxygenase in platelets thereby reducing the thromboxane

Thromboxane is produced by activated platelets during hemostasis it stimulates activation of platelets and platelet aggregation, by activating the thromboxane receptor, which causes change in shape of platelets, activation of integrins, and degranulation of platelets. Circulating fibrinogen binds these receptors on adjacent platelets, further strengthening the clot. It is also a vasoconstrictor

B. It reversibly binds lysine receptor sites on plasminogen. This reduces conversion of plasminogen to plasmin, preventing fibrin degradation .

In secondry polycythemia there is increased tendency for thrombosis, which recruits more platelets for thrombosis and increased fibrin degradation products which may trigger DIC and lead to bleeding