What the difference between using Heparin-DTT and Heparin-ThT to promote tau aggregation? What the difference betw...

Question

Question

What the difference between using Heparin-DTT and Heparin-ThT to promote tau aggregation?

Answer 1

Answer #1

Let us first discuss What is Tau?

Tau is basically a protein which help in stabilizing microtubules.

Using Heparin DTT in decondensation mechanism is useful.

Heparin DTT is mostly used in decondensing.

DTT (Dithiothreitol) is basically a reducing agent to which decondensing agents are added.

Neurodegenerative diseases like Alzheimer disease has tangled neurofibrills.

So, the Heparin helps in detangling these.

DTT helps detangle fibrils under reducing conditions, thus resolving dementia caused.

Heparin ThT (Thioflavin T) helps binding by different mode to tau aggregation.

In this way, they work differently.

Answer 2

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