Question

Use retrosynthetic analysis to suggest a way to synthesize 2,3-dimethyl-3-pentanol using the Grignard reaction. (Click and drag the appropriate images to the reactant positions in the following reaction.)Use retrosynthetic analysis to suggest a way to synthesize 2,3-dimethyl-3-pentanol using the Grignard reaction. (Click and drag the appropriate images to the reactant positions in the following reaction.)

Use retrosynthetic analysis to suggest a way to synthesize 2,3-dimethyl-3-pentanol using the Grignard reaction. (Click and drag the appropriate images to the reactant positions in the following reaction.)

Answer 1

Concepts and reason

Retrosynthetic analysis:

• It is a way of planning an organic synthesis in which it involves transformation of complex target molecule to simple precursor structures.

• The reagent in which it donates electrons and undergoes the formation of a new carbon–carbon bond is known as the Grignard reagent.

• The Grignard reagent is an organometallic reagent with a formula ${\rm{RMgX}}$ . Here, ${\rm{R}}$ represents the alkyl group or aryl group, ${\rm{Mg}}$ represents magnesium, and ${\rm{X}}$ represents halogen.

• In this reagent, ${\rm{R}}$ (alkyl group or aryl group) acts as a nucleophile.

Fundamentals

In ketones, the Grignard’s reaction takes place in two steps:

1)Nucleophilic attack

2)Protonation

Example:

Ans: