The Fischer esterification mechanism is examined in the following two questions in the assignment. Part 1 involves MeOH...

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The Fischer esterification mechanism is examined in the following two questions in the assignment. Part 1 involves MeOH...

The Fischer esterification mechanism is examined in the following two questions in the assignment. Part 1 involves MeOH addition to form the key tetrahedral intermediate. Part 2 will involve loss of H2O to form the ester.

The Fischer esterification mechanism is examined i

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Answer 1

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Answer #1

Concepts and reason

Fischer esterification:

It is an esterification reaction, in which carboxylic acid changes to ester when it reacts with alcohol in the presence of strong acid.

Fundamentals

Mechanism for Fischer esterification reaction:

1)Abstraction of proton from an acid by carbonyl oxygen.

io
H-
+
CL
R7
он
R7
он

2)Nucleophilic attack on carbonyl carbon by oxygen in alcohol.

o
R
Roi
H3C—OH
HC

3)Proton transfer reaction.

Н
өн
нас
Нас

4)Cleavage of water molecule.

т
CH3
нас

5)Deprotonation reaction.

CH3
CH3
RO
R
0

Ans:

H₃COH
OF
:!3—H
нан
H.
com :
Io
of-of-
:0:
CH3
CH3

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Answer 2

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