Question

4. a) Radiopharmaceuticals are utilised for diagnostic imaging and non-imaging nuclear medicine applications. List three properties of a radiopharmaceutical that would make it suitable for diagnostic applications. b) Describe the operation of a radionuclide calibrator for the assay of a radiopharmaceutical. 14] c)9mTc emits gamma rays at 140 keV and 1Csemis gamma rays at 662 keV. Ignoring any other emissions and assuming the same emission probabilities, estimate the calibration factor for 13Cs on a radionuclide calibrator if the factor forT is 1.224 pA/MBq. State any assumptions made. 13]

Answer 1

4a) Radiopharmactutials ase dbugb tat ase boure sub slances . The phakmaceuchcally acive poxhon dutaminas thi adivi Hhat wilt be measured ad the nadicactive posti on enids s cdiation that can te meauuied by the scanner A numb e允0 gaduo platna c uticals are used n human Imagin Tay sharu the physical charactuuisc ot emuting nadiahon ot vasious kinds n bome cases the umitid pasticles oe dekckd either ditect oh indive specialiひd equipmen leg. SPECT, PET, gamma, (Anura, etc.) to generate inaing. gn otheK cases, the agent LJ used to have a tibue ettet Lo pro pettus ot an įdoa1んadiophaんn.qceum cal : slont physical haly wte time eliminated yom tha bods with on ehe dive haly lite time approximatety equalin the esminaton timu To paeverd ybsequund exposue to the bo PuSL pamma emitlor y isomutuc tranwithon gamm0人aus enikłe atould be mo no energetic (n ISO key high speate achvity ) ASU

ie langeb nd quickly at thi tangiti decay into more rtain dangum nucldus ca and echvnly) atachad te the chumical comgound ast Corpou Cheap pre patiend dose · can be easi produced 0L kept at the hospitags he Pkoperties above 아 a Aadioplah ma ceutical that would make it sudable toん diagnoshe applications b) Radio nuclide calibrators ase devies consisthny o onizina chamber ond elecho meto dateckorg. A volume, ot gas İs uont ai nad bchoun two elech cles hao ing a vollage dleunca and thus an lecnc dield behoeen them. Ther 从spond to sdochon by means吋iowization-induced elecmal Jowusation chamber belougs to roup ot gased cuts nts passing Hisough the gas causes ioni zahon The elecmns produced ud atoms by İowuhon aho atwacted too the po tive elechode and low ahve ela chod. , cauing a mo mudoud flow。t a small amo unt wing gersi tive curent dewices called elechomutst Sowzahion chamber sadio nuclide brotsa the total amount o adhivity preud by meauuun the total amoud 吋owtation produced bd the sample and au. calibsotcdl to uad duuedly in units of acivity (8 ot G pi