Question

compare the structures of methotrexate and dihydrofolate. what is the only difference?

COOH COOH HN3 IZ IZ" az H2N Dihydrofolate (DHF) COOH NH ZI COOH H2NN Methotrexate (MTX) Chemical structures of hDHFR ligands. Atom numbering is shown on DHE

Answer 1

Caot :0 CooH 4 HN H NY HN Drhydiofolate In stauctue of Methotsexate Pan ceent Dilydcafelat Cat Curbon maunk ed cus '4 while Cunbonyl Preent In DHF to 'N' manked as lo while His attached methyl oup cctt a ched tD 'N' manked as lo'. MTX in is Pneset 1ह नियमुला Guanine ln DHF In MTX, Adenine CoOH NHL COOH NV MTXI