Question

MEDT 4100 Clinical Virology Case Study 6 Assigned: 11/15/2019, Due: 11/22/2019 Sidra Ilyas Patient 3% year old male presented in August with 2-week history of diarrhea which abated with oral hydration One week later, he developed a fever with temperature of 102.6 and respiratory symptoms. He was found to have some wheezing and right otitis media He was treated with pedale for presumed Chlamydia infection. He continued to have fever and developed irritability and vomit He returned to the clinic and was admitted. Physical exam. On admission, he was writable and had a temperature of 97.9 He had tachycardia with a pulse of 108 beats/min. His tympanic membranes were dull and distorted bilaterally. The rest of the exam was unremarkable Diagnostic Laboratory testing indicated the following Anemia with Hgb=10.4g/dl; WBC count=9,300/ul with 60% lymphocytes, electrolytes were normal Lumbar puncture: CSF WBC-75l with 72% neutrophils, 8% lymphocytes and 20% monocytes, glucose and protein were both normal for the CSF; Gram stain showed no bacteria and few polymorphovuclear leukocytes (PMNS) present: CSF was submitted for viral cultures. He was started on IV ceftriaxone and ampicillin for presumed bacterial meningitis By the second day wis condition had improved Blood, urine and CSF bacterial cultures were negative and he was discharged on the 4th day to complete a 10-day IM ceftriaxone course as an outpatient. After discharge, this CSF viral culture became positive. 1. Does this patient have meningitis? What specific lab results above support your answer? po 107 NO echovirus? axsacker

Answer 1

Patient has no meningitis as csf of the patient with meningitis has low sugar and increased protein level which are normal in given case. Raised wbc in csf is not sensitive indicator of meningitis.

2) picornavirodae

3)oral fecal route, replication in mucosa and lymphoid tissue of tonsils, pharynx and peyers patches , then causes primary viremia lead to spread of virus to receptor bearing target tissue result in second phase of replication that result into sign and symptoms.

4) hepatitis a, myocarditis, encephalitis, common colds, Diarrhea

5) neutralisation test is a specific serological test for this family,

with this test, disease will be diagnosed early so treatment will be started as soon resulting in less hospital stay and cost of care.