(d) Gaba, an important neurotransmitter in the human brain, is involved in epileptic seizures. Below are different form...
(d) Gaba, an important neurotransmitter in the human brain, is involved in epileptic seizures. Below are different forms that may or may not exist (depending on the local pH environment). Gaba has two ionizable functional groups, an amino group and a carboxylic acid, respectively. HON, HINO HN MNOH Hyeon Hawei OH (i) Circle the structure of GABA above that would be dominant at physiological pH = 7. correct answer circled) (2pts for (ii) Below, using the expression from 3(a), justify this choice. In other words, use the Henderson- Hasselbalch equation to estimate the ratio of ſconjugate base]/[acid] for each present in GABA. Show your work for each functional group. You may use the appropriate pKa values from Table 1.8 from your text. To make the estimation simple, just round the pKa if it is shown as a decimal. (3pts for correct work and 1pt for ratio for each functionality; 8pts total) [Note: neutral amines (pKa = 36) are not acidic enough to be dissociated at any cellular pH, but ammonium-like pKa is more useful and can be found in Table 1.81