Question

select the right one :

Question 1: A patient is taking antianginal medication that increases cGMP levels in vascular smooth muscle. The drug is resonsible for this action by :

a) Blockade of B-adrenoreceptors

b) Inhibition of Phosphodieterase

c) Release of nitric oxide

Question 2: A lipid lowering drug known to cause flushing of the skin is:

a) Niacin

b) fish oil

c) Cholestyramine

Answer 1

ANS. 1. The release of nitric oxide in the drug is responsible for an increase in cGMP levels in vascular smooth muscle. nitric oxide activates smooth muscle soluble GC i.e. guanylyl cyclase to form cGMP.

ANS. 2. A lipid-lowering drug known to cause flushing of the skin is Cholestyramine. Cholestyramine lowers the bad cholesterol in the body.