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The first step in this reaction is to reflux acetaminophen in a NaOH/EtOH solution, followed by the addition of but...
for the reaction: acetaminophen + (NaOH/EtOH note: etoh is ethanol) and butyl iodide ---------------> 4-butoxyacetanilide a)...
for the reaction: acetaminophen + (NaOH/EtOH note: etoh is ethanol) and butyl iodide ---------------> 4-butoxyacetanilide a) The first step in this reaction is to reflux acetaminophen in a NaOH/EtOH solution, followed by the addition of butyl iodide. What is the purpose of using the NaOH/EtOH solution? Would the SN2 reaction still occur if the first step was not completed? Why or why not? b) Upon completion of the reaction (before filtration), an additional 4.0 mL of 1.0 M NaOH/EtOH was...
Upon completion of the reaction (before filtration), an additional 4.0 mL of 1.0 M NaOH/EtOH was...
Upon completion of the reaction (before filtration), an additional 4.0 mL of 1.0 M NaOH/EtOH was added to the reaction. What was the purpose of this step? Include a chemical reaction as part of your answer. [2 Marks] n this experiment you synthesize 4-butoxyacetanilide via a Williamson Ether Synthesis. OH 1. NaOH/EtOH 2. 4-butoxyacetanilide acetaminophen
often conducted at reflux? What would be the result of reaction in a round-bottom flask or...
often conducted at reflux? What would be the result of reaction in a round-bottom flask or Erlenmeyer flask with- 1. Define the term "reflux." 2. Why are reactions often conducted at reflux simply boiling this reaction in a round-bottom flask out a reflux condenser? 3. Why must the n-butyl acetate product be rigorously dried prior to in analyor the role of the sodium iodide in today's experiment? Why is only a tiny amount needed? 5. Propose mechanisms for the formation...
please help me answer those three questions according to the oother pictures į CH, CH3 1....
please help me answer those three questions according to the
oother pictures
į CH, CH3 1. NaOMe in MeOH / EtOH, reflux 2. Ethyl lodide, reflux N bolo OH Acetaminophen phenacetini erot!) DAN Procedure: Measure and dispense 0.6 ml of a 4.4 M solution of sodium methoxide in methanol and im of ethanol into a 5 mL reaction vial. Add 215 mmol of acetaminophen (-0.378 8). Set up for reflux in the Tume hood and bring reaction to reflux for...
Procedure: Measure and dispense 0.6 ml of a 4.4 M otion of sodium methoxide in methanol...
Procedure: Measure and dispense 0.6 ml of a 4.4 M otion of sodium methoxide in methanol and me of ethanol into a 5 mL reaction vial. Add 2.5 mmol of acetaminophen (40.378. Set up for reflux in the rume hood and bring reaction to reflux for 15 minutes (solvent is boiling and vapors are condensing condenser). After 15 minutes, directly through the top of the condenser tube, carefully add 0.3 ml of iemy iodide. Continue to reflux for another 45...
C. Indicate which is the late-detemning step. d. Is it the same mechanism as in question...
C. Indicate which is the late-detemning step. d. Is it the same mechanism as in question 1? Why or why not? 3. Explain why El and Sx1 mechanisms follow first order reaction kinetics, whereas E2 and SN2 mechanisms follow second order reaction kinetics. 4. Which is the better nucleophile in a protic solvent: chloride ion or bromide ion? Try to explain this in terms of the nature of the chloride ion and the bromide ion. 5. For the synthesis of...
Show the product of reaction of the indicated ester with LDA, followed by butyl iodide. CHÚCH...
Show the product of reaction of the indicated ester with LDA,
followed by butyl iodide.
CHÚCH 0 1. Provide a correct name for the indicated ester. 2. How many signals would we expect to see in the 13C NMR spectrum? 3. Show the combination of reagents required to synthesize the indicated structure using a Fischer esterification reaction. 4. a. The indicated ester is submitted to Claisen condensation conditions, using the appropriate alkoxide base and a second acidification step. The product...
Reflux procedure and report 1) You start at the same time and in same devices reflux of 40 ml of ...
Reflux procedure and report 1) You start at the same time and in same devices reflux of 40 ml of hexane and in another one 40 ml of benzene. Which device will start reflux first? Explain 2) Why reflux is a referable method of running chemical reactions that require heating? Why not just heat your reaction content in the Erlenmeyer flask? 3) Why do we turn heat off first and water only after your device is at room temperature? 4)...
If you mistakenly extracted the ether solution of the mixture with NaOH first instead of NaHCO3,...
If you mistakenly extracted the ether solution of the mixture with NaOH first instead of NaHCO3, what would happen? And why? Briefly Explain. The three compounds in the mixture were: p-toluic acid(pKa=4.2 strong acid), p-tert butyl phenol(pKa=10.2 weak acid) and acetanilide (pka=20 neutral)
If you were to run this reaction on a 0.5 g acetaminophen, how much powdered potassium...
If you were to run this reaction on a 0.5 g acetaminophen, how
much powdered potassium carbonate would you use ? Show your
work
Alcohols and Ethers 185 14.3 THE WILLIAMSON ETHER SYNTHESIS: PREPARATION OF PHENACETIN FROM ACETAMINOPHEN One of the most common methods used to prepare ether Williamson ether synthesis. In this reaction, an alkoxide anion (RO) acts as a nucleophile in an S, 2 process, displacing a leaving group (X) from an electrophile (R-X). R-20 . RY ROR...
Upon completion of the reaction (before filtration), an additional 4.0 mL of 1.0 M NaOH/EtOH was added to the reaction. What was the purpose of this step? Include a chemical reaction as part of your answer. [2 Marks] n this experiment you synthesize 4-butoxyacetanilide via a Williamson Ether Synthesis. OH 1. NaOH/EtOH 2. 4-butoxyacetanilide acetaminophen
often conducted at reflux? What would be the result of reaction in a round-bottom flask or Erlenmeyer flask with- 1. Define the term "reflux." 2. Why are reactions often conducted at reflux simply boiling this reaction in a round-bottom flask out a reflux condenser? 3. Why must the n-butyl acetate product be rigorously dried prior to in analyor the role of the sodium iodide in today's experiment? Why is only a tiny amount needed? 5. Propose mechanisms for the formation...
please help me answer those three questions according to the
oother pictures
į CH, CH3 1. NaOMe in MeOH / EtOH, reflux 2. Ethyl lodide, reflux N bolo OH Acetaminophen phenacetini erot!) DAN Procedure: Measure and dispense 0.6 ml of a 4.4 M solution of sodium methoxide in methanol and im of ethanol into a 5 mL reaction vial. Add 215 mmol of acetaminophen (-0.378 8). Set up for reflux in the Tume hood and bring reaction to reflux for...
Procedure: Measure and dispense 0.6 ml of a 4.4 M otion of sodium methoxide in methanol and me of ethanol into a 5 mL reaction vial. Add 2.5 mmol of acetaminophen (40.378. Set up for reflux in the rume hood and bring reaction to reflux for 15 minutes (solvent is boiling and vapors are condensing condenser). After 15 minutes, directly through the top of the condenser tube, carefully add 0.3 ml of iemy iodide. Continue to reflux for another 45...
C. Indicate which is the late-detemning step. d. Is it the same mechanism as in question 1? Why or why not? 3. Explain why El and Sx1 mechanisms follow first order reaction kinetics, whereas E2 and SN2 mechanisms follow second order reaction kinetics. 4. Which is the better nucleophile in a protic solvent: chloride ion or bromide ion? Try to explain this in terms of the nature of the chloride ion and the bromide ion. 5. For the synthesis of...
Show the product of reaction of the indicated ester with LDA,
followed by butyl iodide.
CHÚCH 0 1. Provide a correct name for the indicated ester. 2. How many signals would we expect to see in the 13C NMR spectrum? 3. Show the combination of reagents required to synthesize the indicated structure using a Fischer esterification reaction. 4. a. The indicated ester is submitted to Claisen condensation conditions, using the appropriate alkoxide base and a second acidification step. The product...
Reflux procedure and report 1) You start at the same time and in same devices reflux of 40 ml of hexane and in another one 40 ml of benzene. Which device will start reflux first? Explain 2) Why reflux is a referable method of running chemical reactions that require heating? Why not just heat your reaction content in the Erlenmeyer flask? 3) Why do we turn heat off first and water only after your device is at room temperature? 4)...
If you were to run this reaction on a 0.5 g acetaminophen, how
much powdered potassium carbonate would you use ? Show your
work
Alcohols and Ethers 185 14.3 THE WILLIAMSON ETHER SYNTHESIS: PREPARATION OF PHENACETIN FROM ACETAMINOPHEN One of the most common methods used to prepare ether Williamson ether synthesis. In this reaction, an alkoxide anion (RO) acts as a nucleophile in an S, 2 process, displacing a leaving group (X) from an electrophile (R-X). R-20 . RY ROR...
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