Question

3. Use the template in question #1 to summarize all methods to prepare ethers. Substrate Reagent Reaction Scheme Comments Functional group of the product Mechanism (type) Stereochemical Implications (s) Alkyl Halides Alkene

Answer 1

where, Substrated Alkyl halide (1-x) Reagent Any alcohol (R-OH) &, R' = alky poup Base (NaOH ) R-OH + NaOH reacting spuies Iunctional Group of product ether (-OR) RONG Reaction Scheme Net reaction: Rond + R = x R-O-R (ether) Mechanism: Here, backside attaill happens, which Type I leader in SN 2 type reaction. Stereochemical implicabowo If the alkyl halide is Chiral in nature, then as in SN2 reaction, backside allach happens, it inverses the steredhenieten

of the centre Hero, inversion happens as Cominen's ic known Williamson 1. Reaction ether synthess" 2. Presence of base is necessary 3. Best for ress hindered ally halides backside allack preferred] as, then

Substrate – alkene where, R, R, R₂ Ry Reagent Any alcohol and R' =alkyl pour Acidic medium Functional Group of the produce: Ether (-OR) Reaction Scheme + ++ + C (there, Protonation happens in Such a way that more stabilized carbocation is formed. Here, between th and a the first one is more stabilized, so it forms) 1 + -O-R lether Product Mechanisen type t via is Goes via a 2 step reaction carbocation formation, that known as INI reachay.

oroChemical implication!] off the cent bathr the Here, no stereochanical favour is present centre of attacking is clusal, then the enantiomers mirtor image compound) dries 50% - 50% and it become a roletnie mixture (optically inactive). produces R-OH alkene shows wments 1. More subelituated better reactivity. 2. Anhydrous aids do the best 4.0 in acid medium can also reaction, else compete.