Question

Predict the product

NMe2, POCI3 H then H30 1. NaNO2, HCI 2. H20 NH2 ZI

Answer 1

Answer (1):-

CH0 then H₂o

This reaction is Vilsmeier formylation reaction of indole. The reagents used in this reaction are POCl₃ and DMF(N,N - dimethylformamide) . The combination of DMF and POCl₃ generates a carbon electrophile (iminium cation) , which reacts with indole at 3-position. After work-up with aqueous acid , a formyl group (-CHO) is generated at 3- position of indole.

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Answer (2):-

(1) NaNO2, HCl (1) (2) H₂O NH2 NENCO

This reaction is diazotisation reaction of p-toluidine. In this reaction , a solution of p-toludine is prepared in dilute HCl and the solution is cooled in ice -bath . Now, ice cold solution of NaNO₃ is added in solution of p-toludine in HCl to form p-toluenediazonium chloride. p-toluenediazonium chloride, on further, reaction with water form p-methyl phenol.

+ H₂O Oo + N +Her + N₂ + HCl Boil OH NENCE

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