Question

Bob, an online blogger, read an article by Blatherwick et al. "Studies of urinary acidity. Some effects of drinking large amounts of orange juice and sour milk." Journal of Biological Chemistry, 1922. He then wrote online, that if you drink large amounts of sour milk your urine will change to a pH of 5, and if you drink large amounts of orange juice your urine will change to a pH of 8. Adderall is a weak base with a pKa of 10.13. 1) Calculate the ratio of ionized to unionized in urine from a person consuming orange juice and a person consuming sour milk. Show your calculations. 2) If Bob is trying to get the most “bang for his buck” from an Adderall pill, which drink should he drink and why? (6 points)

Based on your above answers and knowledge from this course, what concerns would you have about administration of the oral dose rectally and adjusting urinary pH? (4 points)

Draw a plasma concentration time graph for Bob taking Adderall rectally with the drink that gives him the most “bang for his bucks”(the drink you selected in ), and Adderall taken rectally with water. Assume water will not affect normal urine pH. (4 points)

Will changing the urine pH by drinking different beverages have effect on the glomerular filtration, tubular secretion, and/or tubular reabsorption of Adderall? How might this change the clearance of Adderall

Answer 1

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ionized ferur - 166-7 Un-ionged fem O.006 BHT Auhing Iang PH- perron a augul IS the pha ley + BH 3l0.13 t B BHT -2-13= B BHt 0.12- GB BHT BHT 3.33

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