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2) Consider the picture of SRT1720 shown below (SRT1720 was originally designed to alter Sirtuin signaling),...
vi ganisms the evidence comes from a Llinical trials (or approved by the FDA) that alt...
vi ganisms the evidence comes from a Llinical trials (or approved by the FDA) that alt Ildge of trial are they in, and what company owns the drug? 2) Consider the picture of SRT1720 shown below (SRT1720 was origin the following questions: For each benefit, indicate if it comes from activating on ce comes from (e.g, yeast, mice, humans, etc). wat alter the pathway you've chosen? How do they work was originally designed to alter Sirtuin signaling), and answer a)...
that are not directly IVUIVEU I I I 3) Consider the picture of Rapamycin shown below...
that are not directly IVUIVEU I I I 3) Consider the picture of Rapamycin shown below (Rapamycin affects the mTOR pathway), and answer the following questions: a) Which of the groups in red has the most acidic hydrogen? (2 pts) b) Which of the groups in red has the most basic lone pair of electrons? (2 pts) c) The boxed portion of the molecule is a cyclohexane ring that likely exists in a chair conformation. Draw both possible chairs for...
3) Consider the picture of Rapamycin shown below (Rapamycin affects the MTOR pathway), and answer the...
3) Consider the picture of Rapamycin shown below (Rapamycin affects the MTOR pathway), and answer the following questions: a) Which of the groups in red has the most acidic hydrogen? (2 pts) b) Which of the grou ps in red has the most basic lone pair of electrons? (2 pts) c) The boxed portion of the molecule is a cyclohexane ring that likely exists in a chair conformation. Draw both possible chairs for the ring and indicate which is more...
6. (12 pts, 2 pts) Examine the following six pairs of molecules below. For each pair...
6. (12 pts, 2 pts) Examine the following six pairs of molecules below. For each pair of molecules. indicate/circle which of the pair is the most acidic molecule. Also, indicate which of the rules of comparative acidity (resonance, electronegativity, ion size, hybridization, neutral vs ionic) applies for each pair. For your convenience, the acidic hydrogen atoms have been represented in bold. ин vs. (d) VS. NH, Vs. Bн, (1) PH, VS. SbH
2. The structure shown in the picture below is originally at rest and begins to rotate...
2. The structure shown in the picture below is originally at rest and begins to rotate in the direction shown with a constant angular acceleration and acceleration of points A and B? (3 pts) = 0.5 rad/s2. After 4 seconds, what is the velocity 0.5 rad/s 3m
9. Consider the shorthand structure below (which also does not show lone pair electrons on N,...
9. Consider the shorthand structure below (which also does not show lone pair electrons on N, O, or S). H S OH 0 CE (a) (5 pts each) Fill in the correct number next to the atomic symbol, for the molecular formula of this compound. H= C=__ N= S = (b) (5 pts each) For each of the atoms indicated by a, b, c, indicate the hybrid atomic orbitals you would expect it to be using to bond. a =...
6) The compound that can undergo self-condensation in the presence of NaOMe in MeOH Part 1:...
6) The compound that can undergo self-condensation in the presence of NaOMe in MeOH Part 1: [20 marks] Select the best answer for each of the following: 1) Circle the species that is aromatic: [0][0] [] [O] 7) The most acidic compound Ola Tyra oko sya om ugungano 2) Circle the structure that has a heteroatom lone pair in the aromatic pi electron system 8) Each of the following disubstituted aromatics shown below is nitrated. In which of these cases...
5) If 2 mol of A (structure see below) are mixed with 2 mol of B...
5) If 2 mol of A (structure see below) are mixed with 2 mol of B and 1 mol of C and 1 mol of D in 1 L of water, what are the major components of the mixture after acid-base equilibriums have established themselves? Show reaction equations with curved arrows. Indicate lone pairs and formal charges for all atoms in the reactants and products. Explain your answer by showing appropriate pKa values of functional groups potentially involved in transformations...
1-24 need help really lost Proton Transfer: deprotonation D. 1) Add the appropriate curved arrows for...
1-24 need help really lost
Proton Transfer: deprotonation D. 1) Add the appropriate curved arrows for the following deprotonation step. Also add the other product notice how the Tema s can be converted to this by use of a strong base such as sodium a sodium ion (Na) is not drawn, in this case it is just a spectatorio PCW27 - Mechanistic steps - Part Name: Time spent 2) Label the above compounds with the appropriate name from the previous...
can someone answer 7,6, and 2? VU molecules that, in theory the to 103 pts.] What...
can someone answer 7,6, and 2?
VU molecules that, in theory the to 103 pts.] What is the maximum number of water molecule + following molecule could hydrogen bond with? o 4 You need you be able ate 3. [03 pts.) How many carbons are in planar double bond system2 n recive & doncite Ht to hydrogen bend o 2 to 4. [03 pts.] To which compound is the addition of H-Br more highly regioselect regioselective? 25 7 5. [03...
vi ganisms the evidence comes from a Llinical trials (or approved by the FDA) that alt Ildge of trial are they in, and what company owns the drug? 2) Consider the picture of SRT1720 shown below (SRT1720 was origin the following questions: For each benefit, indicate if it comes from activating on ce comes from (e.g, yeast, mice, humans, etc). wat alter the pathway you've chosen? How do they work was originally designed to alter Sirtuin signaling), and answer a)...
that are not directly IVUIVEU I I I 3) Consider the picture of Rapamycin shown below (Rapamycin affects the mTOR pathway), and answer the following questions: a) Which of the groups in red has the most acidic hydrogen? (2 pts) b) Which of the groups in red has the most basic lone pair of electrons? (2 pts) c) The boxed portion of the molecule is a cyclohexane ring that likely exists in a chair conformation. Draw both possible chairs for...
3) Consider the picture of Rapamycin shown below (Rapamycin affects the MTOR pathway), and answer the following questions: a) Which of the groups in red has the most acidic hydrogen? (2 pts) b) Which of the grou ps in red has the most basic lone pair of electrons? (2 pts) c) The boxed portion of the molecule is a cyclohexane ring that likely exists in a chair conformation. Draw both possible chairs for the ring and indicate which is more...
6. (12 pts, 2 pts) Examine the following six pairs of molecules below. For each pair of molecules. indicate/circle which of the pair is the most acidic molecule. Also, indicate which of the rules of comparative acidity (resonance, electronegativity, ion size, hybridization, neutral vs ionic) applies for each pair. For your convenience, the acidic hydrogen atoms have been represented in bold. ин vs. (d) VS. NH, Vs. Bн, (1) PH, VS. SbH
2. The structure shown in the picture below is originally at rest and begins to rotate in the direction shown with a constant angular acceleration and acceleration of points A and B? (3 pts) = 0.5 rad/s2. After 4 seconds, what is the velocity 0.5 rad/s 3m
9. Consider the shorthand structure below (which also does not show lone pair electrons on N, O, or S). H S OH 0 CE (a) (5 pts each) Fill in the correct number next to the atomic symbol, for the molecular formula of this compound. H= C=__ N= S = (b) (5 pts each) For each of the atoms indicated by a, b, c, indicate the hybrid atomic orbitals you would expect it to be using to bond. a =...
6) The compound that can undergo self-condensation in the presence of NaOMe in MeOH Part 1: [20 marks] Select the best answer for each of the following: 1) Circle the species that is aromatic: [0][0] [] [O] 7) The most acidic compound Ola Tyra oko sya om ugungano 2) Circle the structure that has a heteroatom lone pair in the aromatic pi electron system 8) Each of the following disubstituted aromatics shown below is nitrated. In which of these cases...
5) If 2 mol of A (structure see below) are mixed with 2 mol of B and 1 mol of C and 1 mol of D in 1 L of water, what are the major components of the mixture after acid-base equilibriums have established themselves? Show reaction equations with curved arrows. Indicate lone pairs and formal charges for all atoms in the reactants and products. Explain your answer by showing appropriate pKa values of functional groups potentially involved in transformations...
1-24 need help really lost
Proton Transfer: deprotonation D. 1) Add the appropriate curved arrows for the following deprotonation step. Also add the other product notice how the Tema s can be converted to this by use of a strong base such as sodium a sodium ion (Na) is not drawn, in this case it is just a spectatorio PCW27 - Mechanistic steps - Part Name: Time spent 2) Label the above compounds with the appropriate name from the previous...
can someone answer 7,6, and 2?
VU molecules that, in theory the to 103 pts.] What is the maximum number of water molecule + following molecule could hydrogen bond with? o 4 You need you be able ate 3. [03 pts.) How many carbons are in planar double bond system2 n recive & doncite Ht to hydrogen bend o 2 to 4. [03 pts.] To which compound is the addition of H-Br more highly regioselect regioselective? 25 7 5. [03...
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