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Please draw out the full mechanism with intermediates of this reaction scheme. Thanks. Reductive amination is...
1. Reductive amination (Carey, Section 22.10) is an important C-N bond forming strategy widely used in the synthesis of biologically active natural product. It's a powerful and reliable strategy that avoids the problem of overalkylation that often accompanies direct alkylation of amines with alkyl halides (Figure 1). secondary amine r tiary amine quemary sa Figure 1: Yields are generally poor as product amines are more nucleophilic and can also react with halide. The result is often a mixture of amines...
Reductive Amination Write down a reaction scheme for the synthesis od N-benzyl alanine methyl ester hydrochloride. (Reagents are methyl pyruvate, benzylamine, sodium triacetoxyborohydride) Maybe helpful: Scheme 1:Formation of an N-substituted imine(Shiff base) through the reaction between a carbonyl-containing compound and a primary amine Scheme 2: Imine reduction yields an amine
Multistep Synthesis: Synthesis of Amine (Organic Chemistry Lab) Question 1. Explain each step of reaction mechanism. (How does it work?) 2. Discuss reason for reaction sequence. (Why must one reaction occur before another?) 3. Explain how IR supports the major product. Experiment Procedure Imine Formation: Weigh a 20 mL beaker and then add 380 mg of ortho-vanillin and 268 mg of para-toluidine. Care should be taken to add equivalent molar amounts of the two reactants. Observe the mixture and record...