Question

QUESTION 2 An 18 yr old man presents with tall stature, poorly developed hair growth on face and body and significant gynecomastia. On examination, he was found to have lower than average testes and penile size and reported no ability to develop erections. He does not report any instances of childhood mumps or testicular injury. His biochemical testing results came back as: Sperm count: Negligible FSH: 33.5 U/L (0.1- 10U/L) LH: 19 U/L (1.24-7.8 U/L) Testosterone: 7nmol/L (12-30nmol/L) a. What is the likely diagnosis in this case? b. What genetic test would you use to confirm the diagnosis? c. What are the biochemical abnormalities seen in the results above? Explain the connection between the FSH, LH and testosterone levels. d. What treatment options is available to this patient to restore sexual function? e. How would treatment options differ if the patient desires fertility at a later time? Explain why a different treatment option might be needed.

Answer 1

A. Male hypogonidism in which there is less secretion of testosterone resulting in poor musculine growth and development during puberty

B. Blood level of testosterone level

C there are no sperms in semen, FSH and LH levels are more wheras testosterone level is low . In male hypogonadism, there is low testosterone level but to increase the secretion, pituitary produces FSH and LH more.

D. Testosterone replacement therapy is the treatment.

E. In men with hypogonadotropic hypogonadism desiring fertility, human chorionic gonadotropin (hCG) alone or in combination with human menopausal gonatotropins (hMG) can be used to induce spermatogenesis and fertility.