Question

In each reaction box, place the best reagent and cHi I need some help with these reagents! Thanks!

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Answer #1
Concepts and reason

The concept is to synthesize imine form amide, and 4-methoxybutan-2-one from ethyl 3-oxobutanoate by using the list of reagents provided.

Fundamentals

Conversion of ethyl amide to imine occurs in three steps. They are

1.Hydrolysis

2.Reduction

3.Oxidation

4.Nucleophilic addition reaction

Conversion of ethyl 3-oxobutanoate to 4-methoxybutan-2-one occurs in three steps. They are

1.Protection of ketone

2.Reduction of ester

3.Deprotection of ketone

The reaction is,

14,0%, 40, hent
1) H30+, H20, heat
i
-NH₂
OH
propionamide
propionic acid

The reaction is,

2) LiAlH4
OH
3) H20
OH
propionic acid
propan-1-ol

The reaction is,

༢.jpcc.
4) PCC
OH
propan-1-ol
propionaldehyde

The reaction is,

5) NH2CH2CH3, H3O+ (cat)
H
propionaldehyde
(E)-N-propylideneethanamine

The reaction is,

DHOCHSCH.Oh. en or
1) HOCH,CH,OH, cat, H+
ó
o
i
ethyl 3-oxobutanoate

The reaction is,

2) LiAlH4
ОН

The reaction is,

e o
2) H20, H307
en
OH
OH
4-hydroxybutan-2-one

Ans:

Thus, the correct choice of reagents is,

1) H30+, H20, Heat
2) LiAlH4
3) H20
4) PCC
5) NH2CH2CH3, H30+ (cat)

Thus, the correct choice of reagents is,

1) HOCH2CH2OH, cat, H
2) LiAlH4
3) H20, H30+

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