Question

3. Familial hypercholesterolemia shows incomplete dominance. Allele HN codes for a normal LDL receptor. Allele Hs codes for inability to make a LDL receptor. HNHN individuals are normal. Individuals with the HSH genotype have severe hypercho- lesterolemia. Heterozygous (HNHS) types will have a mild form of the disease. If a woman who has normal LDL recep trait, what types of genotypes and phenotypes are possible for their offspring? Draw tors marries a man who is heterozygous for this a Punnett square.

Answer 1

The genotype of the woman with normal LDL receptors will be H^N H^N The genotype for the man with heterozygous trait for LDL receptor will be H^N H^S Now let us draw the Punnet square for this condition Possible genotypes for the offspring would be H^N H^N and H^H^S Possible phenotypes for the offspring will be 50 % normal LDL receptors and 50 % will suffer from mild form of familial hypercholesterolemia.