6. (24 pts) Complete the reactions shown below, remember to show all relevant stereochemistry. For products...
Complete the rearions shown below, remember to show all relevant stereochemistry. For products only draw the major product, if the conditions yield no reaction indicate, no reaction. Br CH2 NaOH Colon 501 od 2 OH NaBr -
3. (28 pts) Draw the starting material, reagents, or major products of the following reactions. Indicate stereochemistry where relevant. - 5 mino cat. NaOCH CH, OH bo He° °CH °CH, Z HOA L ambe also THF, CO, : HO. HO H. CH, OH en generall HD, HD
3. Devise S2 reactions that would lead to the following products. Show stereochemistry where relevant. CH DMF + NaBr nucleophile alkyl halide N сн,он nucleophile alkyl halide THF LICI nucleophile alkyl halide 4. Show how the compounds below can be made in two ways in one reaction from the appropriate starting materials. a) a cuprate a different cuprade b) an alkene an alkyne
16. Propose structure(s) for major organic product(s) of the following reactions. Show all relevant stereochemistry. (3pts. each, 24 pts. total) OCH3 NaOCH, CH OH HaCO 1. (CH3 CuLi 2. H20
4. (6 pts) Predict the major product for the following reactions. Remember to indicate stereochemistry, when appropriate. Unless otherwise noted you may assume that each reagent is available in excess. If no reaction is expected, write NR. 1 H2O OTS NaSH ü Nash DMSO Br QB CH,OH CH3OH
4. (31 pts) Provide the reaction products and indicate the type of reactions ( I, UL, TE EZ) and optical activity (Yes or No) in the round rectangles, respectively. If reaction does not take place, indicate "No Reaction" in the box Draw 2 major products Reaction type Snd Draw 1 minor product Reaction type EL VW Is the product optically active? ha Draw 1 product Reaction type EZ Сн,он NaCN acetone Is the product optically active? ho Br Draw 1...
Mini-Spiderweb (16 pts, 2pts/box). Please complete the following reaction spiderweb with the appropriate starting materials, reagents or products. Pay attention to stereochemistry, and for product boxes – include only the major product(s), unless otherwise noted. E1 and Sn1 (5 pts). The following alkyl halide will undergo both E1 and Sn1 mechanisms to give a slew of products when exposed to water. Please draw them all in the box below. Remember to consider rearrangements and account for all stereoisomers formed. Mini-Spiderweb...
Indicat II. REACTIONS: Give the MAJOR organic products of each of the following reactions. Stereochemistry where appropriate. [3 points cach] нусЗн H. CH CH,CH,OH H2SO NBS DMSO, HO " Học &H 1) NaOCH 2) H₃0 нс" н OH 1) TSCI, pyridine HD 2 0
8. [18 pts) Provide the expected organic product(s) from each of the reactions below. Ignore the stereochemistry. No mechanism required! (3 points for each organic product, switching the major and minor will be penalized) a. Major: NaOCH; E2 Br b. Major Minor OH E2 Br 3 products in total CH,OH ΕΙ 6. 19 pts] For each of the following reactions, give the organic product(s), and include the stereochemistry when applicable. No mechanism required! (3 points for each organic product) a....
4. (31 pts) Provide the reaction product(s), and indicate the type of reactions (S1, S2, E1 and E2) and optical activity (Yes or No) in the round rectangles, respectively. If reaction does not take place, indicate "No Reaction" in the box. Draw 1 minor product Reaction type Reaction type Draw 2 major products Is the product optically active? Reaction type Draw 1 product CH2OH Is the product optically active? NaCN acetone Br Reaction type Draw 1 product LDA secondary alkyl-bromide...