Answer the following questions about erlotinib and phomallenic acid C. Erlotinib, sold under the trade name Tarceva, was introduced in 2004 for the treatment of lung cancer. Phomallenic acid C is an inhibitor of bacterial fatty acid synthesis.
a. Which C - H bond in erlotinib is most acidic?
b. What orbitals are used to form the shortest C– C single bond in erlotinib?
c. Which H atom in phomallenic acid C is most acidic?
d. How many sp hybridized carbons are contained in phomallenic acid C?
e. Rank the labeled bonds in phomallenic acid C in order of increasing bond strength.
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