Many tumors of the breast are correlated with estrogen levels in the body. Drugs that interfere with estrogen binding have antitumor activity and may even help prevent tumor occurrence. A widely used antiestrogen drug is tamoxifen.
(a) Name the functional groups in tamoxifen.
(b) Classify the amino group in tamoxifen as primary, secondary, or tertiary.
(c) How many stereoisomers are possible for tamoxifen?
(d) Would you expect tamoxifen to be soluble or insoluble in water? In blood?
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