Analyzing the energetics of coupled reactions
The acyl-CoA synthetase reaction activates fatty acids for oxidation in cells:
R-COO- + CoASH + ATP →R-COSCoA + AMP + pyrophosphate
The reaction is driven forward in part by hydrolysis of ATP to AMP and pyrophosphate. However, pyrophosphate undergoes further cleavage to yield two phosphate anions. Discuss the energetics of this reaction both in the presence and absence of pyrophosphate cleavage.
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