Malaria is caused by protozoan apicomplexan species of Plasmodiumspread by Anophelesmosquitoes. The organism replicates in red blood cells of the host and are released in waves that result in cyclic presentation of symptoms. African sleeping sickness is caused by protozoan kinetoplastid species of Trypanosoma spread by tsetse flies of the genus Glossina.They also produce waves of symptoms as the organisms switch antigen surface proteins.