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Solutions For An Introduction to Medicinal Chemistry Chapter 5 Problem 8Q

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Solution 1

Antibodies are the proteins produced by the cells of an immune system in response to the attack of an antigen or foreign particle. The antibody can be either soluble or membrane-bound. It can be secreted by the plasma cells or serve as a receptor on the B-lymphocytes. Thus, antibodies are generated to recognize the extracellular regions of growth factor receptors.

The binding of the antibody to the receptor of a growth factor should prevent the growth factor to reach its binding site, which, in turn, blocks its signal. It has been observed that sometimes the signal same as that of the growth factor is triggered by an antibody. The formation of dimers is involved in activating the growth factors.

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Figure: Structure of an antibody

An antibody molecule is generally a Y-shaped structure, which consists of heavy and light chains. The tip of each arm of Y can bind to the receptors of a particular molecule serving as a bidentate ligand. Thus, two different receptors can bind with one antibody, which results in dimerization. This further causes the activation of the growth factors.

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