Loss of water from two molecules of a carboxylic acid forms an acid anhydride. Acid anhydrides are also carboxylic acid derivatives—the OH group of the carboxylic acid has been replaced with a carboxylate group. Thus, the carboxylate group is the leaving group of an acid anhydride.
What is the product of the reaction of acid anhydride with
a. an alcohol?
b. an amine?
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